![]() ![]() ![]() It also affects the expression of bacterial DNA and binds to DNA ( Kang et al., 2015 Du et al., 2020). In addition, berberine can also affect the integrity and permeability of bacterial cell membranes, and bind to some proteins on the cell membrane, thereby affecting the structure and function of proteins. Berberine can inhibit the formation of extracellular amyloid peptides in bacteria, thus, interfering with the formation and stability of biofilms ( Peng et al., 2015 Wang et al., 2018). Berberine hydrochloride has certain bacteriostatic and bactericidal effects on Candida albicans, Trichophyton mentagrophytes, and Staphylococcus aureus ( Zhang et al., 2013 Zorić et al., 2017 Xiao et al., 2019). It has been studied widely in biochemistry and pharmaceutical chemistry and found to have antitumoral, antibacterial, and antioxidant ( Domadia et al., 2008) activities both in vivo and in vitro. japonica.īerberine hydrochloride is a natural isoquinoline alkaloid and the main active ingredient of several herbal medicines commonly used clinically, such as Coptis chinensis and Phellodendri ( Habtemariam, 2016) berberine hydrochloride is the most important bioactive component in Phellodendron chinensis, accounting for about 0.6% of Phellodendron chinensis extract and 1.6% of berberine ( Anna et al., 1995 Lu-Yang et al., 2014). The results of this study provide a new understanding of the potential role of berberine hydrochloride on the oxidative stress mechanisms of C. The glutathione transferase activity in the hepatopancreas was significantly increased in berberine hydrochloride-treated C. hydrophila were significantly increased compared with those only infected with A. The activities of glutathione peroxidase, superoxide dismutase, and catalase in the hepatopancreas of berberine hydrochloride-treated C. japonica were further increased by adding berberine hydrochloride and were increased the highest at a concentration of 300 mg/L. hydrophila were all higher than the control. The transcription levels of PXL2A infected with A. Pr圆 was different from Prx5 and PXL2A in the Peroxiredoxin family. The Prx5 conserved domain contains three important Cys loci, Cys75, Cys100, and Cys76. Pr圆 and PXL2A each have one conserved domain, Cys44, and Cys81. The full-length cDNA of Pr圆 and the ORFs of Prx5 and PXL2A were cloned. hydrophila after being submerged in different concentrations (0, 100, 200, and 300 mg/L) of berberine hydrochloride for 48 h. ![]() japonica infected with Aeromonas hydrophila. We studied the molecular mechanism of oxidative stress in berberine hydrochloride-treated C. Charybdis japonica is one of the main economic species of crab in Southeast Asia. ![]() 6Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Chinaīerberine hydrochloride is an isoquinoline alkaloid, which has antitumoral, antibacterial, and antiviral activities in vivo and in vitro.5Nanjing University of Information Science and Technology, Nanjing, China.4Southern Marine Science and Engineering Guangdong Laboratory (Zhuhai), Zhuhai Key Laboratory of Marine Bioresources and Environment, Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, School of Marine Sciences, Sun Yat-Sen University, Guangzhou, China.3Institute of Marine Biology, College of Oceanography, Hohai University, Nanjing, China.2Biology Program, School of Distance Education, Universiti Sains Malaysia, Penang, Malaysia.1Freshwater Fisheries Research Institute of Jiangsu Province, Nanjing, China.Mingming Han 2, Tianheng Gao 3, Yuxin Liu 5, Zakaria Zuraini 2, Chenxi Zhu 1, Tongqing Zhang 1, Feng Ji 6, Qichen Jiang 1* and Xian Sun 4* ![]()
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